Orbit

交通大学-生物科技学院

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研究领域

生医工程研究室    林志生博士(Biomedical Engineering Lab – PI: Dr. Chih-Sheng Lin)
  • 探讨心血管疾病中心脏组织之纤维化病变的分子调控机制
  • 发展临床与食品病原体检测用之生物传感系统
  • 利用微藻技术进行二氧化碳的减量与生产生质柴油
  • Structure prediction and classification
  • Prediction of protein subcellular localization
  • Disulfide proteins
  • Protein stability
  • Structural alignment
  • Molecular Simulation
  • Sequence coupling
  • Systems Biology: gene regulatory network, optimization of energy function
  • Computational Biology: protein structural prediction, protein-ligand docking
  • Microarray analysis: Gene expression data analysis, Feature selection and classification
  • Evolutionary Computation: intelligent evolutionary algorithms, optimization problem solving
  • Machine Learning: pattern recognition, data mining, artificial intelligence
  • Optimization theory: combinatorial optimization, optimization of large-scale systems
  • Biochemistry and molecular biology          
  • Bioelectronics: Enzyme chip and microfluid system for biomolecular separation and direct detection
  • Bioinformatics
  • Biochemical ecology: Proteomics of seed germination and Enzymatic response to environmental pressure
  • 基因体与系统生物学
  • 生物能源与生物燃料电池
  • 生合成药物之基因选殖与表现
  • 环境生物技术
  • 奈米生医材料干细胞组织工程
  • 酵素工程开发 
  • Protein-Ligand Docking / Virtual Drug Screening (GEMDOCK)
  • Computer-aided Drug Design (QSAR/Toxicity prediction) (GEMDOCK)
  • Systems Biology: Protein-Protein (Protein-DNA) Interaction/Docking & Pathway (DAPID)
  • Protein Folding [(PS)2] & Structural Bioinformatics (3D-BLAST)
  • Machine Learning and Applications: Genetic algorithms, evolution strategies, and evolutionary programming


心脏电气学及心血管生物资讯学研究室    杨腾芳博士
( Electrocardiology and Cardiovascular Bioinformatics Lab – PI: Dr. Ten-Fang Yang )
  • 平均讯号心电图,时域领域及频率领域之信号分析研究。
  • 心率变异性,时域领域及频率领域之信号分析研究。
  • 血液透析肾衰竭病患之平均讯号心电图之研究。
  • 血液透析肾衰竭病患之心率变异性之研究。
  • 平均讯号心电图,性别、年龄、种族差异之研究。
  • 心率变异性,性别、年龄、种族差异之研究。
  • 正常台湾人之平均讯号心电图研究。
  • 正常台湾人之心率变异性研究。
  • 心脏猝死之病因及心脏电气学侦测方式之研究。
  • 标准12导程心电图在心脏学之研究。
  • 向量心电图在心脏电气学之研究。
  • 平均讯号心电图模式分析研究。
  • Bioinorganic chemistry and molecular imaging
  • Paramagnetic metal complex and bio-activated metal complex for magnetic resonance imaging;
  • Superparamagnetic iron oxide nanoparticle (SPIO) for magnetic resonance imaging;
  • Contrast agent for molecular imaging;
  • Probe for optical imaging 

  • 蛋白质之作用原理机制
  • 蛋白质结构与功能
  • 病毒与生长与分子交互作用
  • 伺机性病原菌克雷白氏肺炎杆菌、绿脓杆菌、创伤弧菌致病因子分子调控之研究。
  • 克雷白氏肺炎杆菌及绿脓杆菌中双分子讯息传递系统之交互作用。
  • 克雷白氏肺炎杆菌及创伤弧菌中GGDEF与EAL蛋白质于环状二鸟甘酸 (Cyclic di-GMP) 讯息传递途径之角色。
  • 全基因体化分析克雷白氏肺炎杆菌之纤毛表现与相互调控。
  • The structure-function-mechanism and molecular evolution studies of oxidosqualene cyclase enzymes
  • The detection and functional characterization of microbial virulence factors
  • The Research on the biosolar energy device design
  • The Chinese Herb Screening for Anticancer and Anti-inflammatory Therapy
  • The structure-function relationships study of metallopeptidase
  • 白色念珠菌形态/毒性因子之功能性研究。
  • 白色念珠菌抗药因子之功能性研究。
  • 白色念珠菌形态/毒性因子与抗药因子之交互作用研究。 
  •  真菌感染之流行病学。
  • 登革热.病毒基因之功能性研究。
  • 抗登革热.病毒及抗真菌之研发。
  • 微生物与寄主之交互作用。
  • 研究并暸解Mst3所引发细胞凋亡之分子机转。
  • 研究 Mst3 在妇女怀孕期病变 (如妊娠毒血症及早产等) 过程中之角色
  • 开发生物奈米装置于细胞影像及癌症治疗 
  •  研发相关生物传感技术于诊断与食品检验
  • Protein Folding
  • Functional guided protein-protein interaction networks
  • Novel functional biomaterial development
  • Single molecule manipulation and imaging. 
  • Novel functional biomaterial complex development and application
  • Nanobioelectronics
  • Synthetic and Systems Biology
  • microRNA regulation
  • Post-transcriptional regulation and RNA processing
  • Post-translational modification (PTM)
  • Proteomics
  • 抗癌标靶
  • 抗癌药物 
  •  抗癌奈米

  • 免疫学
  • 微脂体
  • 抗体之制作
  • 蛋白质工程
  • Theoretical coordination chemistry
  • Studies in spectroscopy
  • Benchmark in high-performance computing
  • Dr. Lin’s lab is interested in developing and applying methods and tools in Bioinformatics to study various problems in Genomics, Structural Biology, and Evolutionary Biology.
  • 认知神经科学
  • 生医讯号处理
  • 神经可塑性
  • 语音编码的神经机制
  • 耳鸣成因的神经生理机转
  • Cellular morphogenesis is the process by which the size or shape of a cell is generated and organized to adapt to certain developmental or environmental changes. The Hwang lab is particularly interested in a morphogenetic process termed neuritogenesis, through which a nerve cell generate its elongated axon and dendrites. It is the fundamental process underlying the establishment and plasticity of neuronal networks. Neuritogenesis can be generally categorized into several distinct steps: neurite initiation, neurite elongation, axonal polarization and growth, dendritic growth, and axon/dendrite maturation.
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